Ac-VDVAD-CHO

• Description :

  Ac-VDVAD-CHO is a caspase-2/3 inhibitor (IC50: 46 and 15 nM) [1].

• UNSPSC :

  12352209

• Target :

  Caspase

• Type :

  Peptides

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/ac-vdvad-cho.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@H](C=O)CC(O)=O)=O)=O)=O)=O)=O

• Molecular Formula :

  C23H37N5O10

• Molecular Weight :

  543.57

• References & Citations :

  [1]Maillard MC, et al. Exploiting differences in caspase-2 and -3 S₂ subsites for selectivity: structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors. Bioorg Med Chem. 2011 Oct 1;19 (19) :5833-51.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• Isoform :

  Caspase 2; Caspase 3

• CAS Number :

  [194022-51-0]