Ac-DEVD-CHO

• Description :

  Ac-DEVD-CHO is a Caspase-3 inhibitor with a Ki value of 230 pM.

• UNSPSC :

  12352209

• Hazard Statement :

  H302, H312, H332

• Target :

  Caspase

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Ac-DEVD-CHO.html

• Purity :

  99.76

• Solubility :

  10 mM in DMSO|H2O : ≥ 50 mg/mL

• Smiles :

  O=C(N[C@@H](C(C)C)C(N[C@H](C=O)CC(O)=O)=O)[C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC(O)=O)=O

• Molecular Formula :

  C20H30N4O11

• Molecular Weight :

  502.47

• Precautions :

  H302, H312, H332

• References & Citations :

  [1]Garcia-Calvo M, et al.nhibition of human caspases by peptide-based and macromolecular inhibitors. J Biol Chem. 1998 Dec 4;273 (49) :32608-13.|[2]Jinglin Wang, et al. A polysaccharide from Lentinus edodes inhibits human colon cancer cell proliferation and suppresses tumor growth in athymic nude mice. Oncotarget. 2017 Jan 3; 8 (1) : 610-623.|[3]Junping Zhang, et al. Hypericin-mediated photodynamic therapy induces apoptosis of myoloma SP2/0 cells depended on caspase activity in vitro. Cancer Cell Int. 2015; 15: 58|[4]Long-gang He, et al. Sinomenine induces apoptosis in RAW 264.7 cell-derived osteoclasts in vitro via caspase-3 activation. Acta Pharmacol Sin. 2014 Feb; 35 (2) : 203-210.|[5]Liu LX, et al. The effect of caspase-3 inhibitor on the concentrations of serum inflammatory cytokines in sepsis related acute kidney injury induced by peritoneal cavity infection in mice. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2010 Dec;22 (12) :736-9.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Caspase 1; Caspase 10; Caspase 2; Caspase 3; Caspase 4; Caspase 5; Caspase 6; Caspase 7; Caspase 8; Caspase 9

• CAS Number :

  [169332-60-9]