Ac-​IETD-​CHO

Ac-​IETD-​CHO

• CAS Number: 191338-86-0
• UNSPSC Description: Ac- IETD- CHO is a potent, reversible inhibitor of granzyme B and caspase-8. Ac- IETD- CHO inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failure. Ac- IETD- CHO also inhibits cytotoxic T lymphocytes induced cell death[1][2].
• Target Antigen: Apoptosis
• Type: Peptides
• Related Pathways: Apoptosis
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ac-ietd-cho.html
• Solubility: 10 mM in DMSO
• Smiles: CC[C@H](C)[C@H](NC(C)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@H](C=O)CC(O)=O)=O)=O)=O
• Molecular Weight: 502.52
• References & Citations: [1]Bajt ML, et al. Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for a postmitochondrial processing of caspase-8. Toxicol Sci. 2000 Nov;58(1):109-17.|[2]Hayashida M, et al. Cell death induction by CTL: perforin/granzyme B system dominantly acts for cell death induction in human hepatocellular carcinoma cells. Proc Soc Exp Biol Med. 2000 Nov;225(2):143-50.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported