PDGFRα/FLT3-ITD-IN-2

• CAS Number:

  2761259-09-8

• UNSPSC Description:

  PDGFRα/FLT3-ITD-IN-2 (Compound 13d) is a potent inhibitor of PDGFRα/FLT3 with IC50s of more than 20 and 1.654 μM, respectively. PDGFRα/FLT3-ITD-IN-2 has the potential for the research of acute myeloid leukemia or chronic eosinophilic leukemia[1].

• Target Antigen:

  FLT3; PDGFR

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pdgfrα-flt3-itd-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NCCCCNC(C1=CC=C(C=C1)CNC2=NC(N[C@H]3CC[C@@H](CC3)N)=NC4=C2N=CN4C5CCCC5)=O

• Molecular Weight:

  519.68

• References & Citations:

  [1]Vlková K, et al. Synthesis and biological activity evaluation of novel 2,6,9-trisubstituted purine conjugates as potential protein kinases inhibitors. Bioorg Med Chem Lett. 2022 Mar 15;60:128603

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported