PDGFRα/FLT3-ITD-IN-2

PDGFRα/FLT3-ITD-IN-2

• CAS Number: 2761259-09-8
• UNSPSC Description: PDGFRα/FLT3-ITD-IN-2 (Compound 13d) is a potent inhibitor of PDGFRα/FLT3 with IC50s of more than 20 and 1.654 μM, respectively. PDGFRα/FLT3-ITD-IN-2 has the potential for the research of acute myeloid leukemia or chronic eosinophilic leukemia[1].
• Target Antigen: FLT3; PDGFR
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pdgfrα-flt3-itd-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: NCCCCNC(C1=CC=C(C=C1)CNC2=NC(N[C@H]3CC[C@@H](CC3)N)=NC4=C2N=CN4C5CCCC5)=O
• Molecular Weight: 519.68
• References & Citations: [1]Vlková K, et al. Synthesis and biological activity evaluation of novel 2,6,9-trisubstituted purine conjugates as potential protein kinases inhibitors. Bioorg Med Chem Lett. 2022 Mar 15;60:128603
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported