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FLT3/ITD-IN-2

CAT: 0931-T63274-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T63274-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2489446-59-3
Target
Others, FLT
Related Pathways
Others, Tyrosine Kinase/Adaptors, Angiogenesis
Bioactivity
FLT3/ITD-IN-2 is a potent inhibitor of FLT3-ITD and is able to act on FLT3D835Y (IC50: 0.3 nM), FLT3 (IC50: 0.4 nM) and FLT3-ITD (IC50: 1.0 nM) .FLT3/ITD-IN-2 effectively inhibits the phosphorylation of FLT3 and is able to effectively inhibit the proliferation of acute myeloid leukemia cells.
Smiles
C(NC1=C(C(F)(F)F)C=C(C=C1)N2CCOCC2)(=O)C3=C4N(N=C3)C=CC(N[C@@H]5CCCNC5)=N4
Molecular Formula
C23H26F3N7O2
Molecular Weight
489.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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