SI-109

• Description:

  SI-109 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3 μM) . SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 degrader SD-36[1].

• UNSPSC:

  12352005

• Target:

  Ligands for Target Protein for PROTAC; STAT

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling; PROTAC; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/si-109.html

• Purity:

  99.91

• Solubility:

  DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C ([C@@H] (NC ([C@@H]1CC[C@H] (CCN (C (C) =O) C[C@@H]2NC (C3=CC (C=C (C (F) (P (O) (O) =O) F) C=C4) =C4N3) =O) N1C2=O) =O) CCC (N) =O) NC (C5=CC=CC=C5) C6=CC=CC=C6

• Molecular Formula:

  C40H44F2N7O9P

• Molecular Weight:

  835.79

• References & Citations:

  [1]Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36 (5) :498-511.e17.

• Shipping Conditions:

  Dry Ice

• Storage Conditions:

  -80°C, stored under nitrogen

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  STAT3

• CAS Number:

  2429877-30-3