SI-109

• Description :

  SI-109 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3 μM) . SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 degrader SD-36[1].

• UNSPSC :

  12352005

• Target :

  Ligands for Target Protein for PROTAC; STAT

• Type :

  Reference compound

• Related Pathways :

  JAK/STAT Signaling; PROTAC; Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/si-109.html

• Purity :

  99.91

• Solubility :

  DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C([C@@H](NC([C@@H]1CC[C@H](CCN(C(C)=O)C[C@@H]2NC(C3=CC(C=C(C(F)(P(O)(O)=O)F)C=C4)=C4N3)=O)N1C2=O)=O)CCC(N)=O)NC(C5=CC=CC=C5)C6=CC=CC=C6

• Molecular Formula :

  C40H44F2N7O9P

• Molecular Weight :

  835.79

• References & Citations :

  [1]Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36 (5) :498-511.e17.

• Shipping Conditions :

  Dry Ice

• Storage Conditions :

  -80°C, stored under nitrogen

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  STAT3

• CAS Number :

  [2429877-30-3]