SI-2

• Description :

  SI-2 (EPH 116) is an inhibitor for steroid receptor coactivator-3 (SRC-3), which reduces the transcriptional activity and protein concentration of SRC-3 in cells, exhibits cytotoxicity in cancer cell, inhibits migration of MDA-MB-468, induces apoptosis of MDA-MB-468. SI-2 inhibits the tumor growth in mouse models, without significant toxicity for heart and other major organs (20 mg/kg) [1].

• Product Name Alternative :

  EPH 116

• UNSPSC :

  12352005

• Target :

  Apoptosis; Src

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/si-2.html

• Smiles :

  CN1C(N/N=C(C)/C2=CC=CC=N2)=NC3=CC=CC=C13

• Molecular Formula :

  C15H15N5

• Molecular Weight :

  265.31

• References & Citations :

  [1]Song X, et al., Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc Natl Acad Sci U S A. 2016 May 3;113 (18) :4970-5.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [223788-33-8]