KRP-109

CAT: 0804-HY-11046ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-11046ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KRP-109 is a neutrophil elastase (NE) inhibitor with activity in reducing lung inflammation. KRP-109 improves survival in mouse models and reduces the number of neutrophils and inflammation in the alveolar walls. KRP-109 significantly reduced cell and neutrophil counts in bronchoalveolar lavage fluid, as well as cytokine levels such as interleukin 1β and macrophage inflammatory protein 2. KRP-109 can be used in the research of severe pneumonia[1].
CAS Number
[1275996-50-3]
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/krp-109.html
Smiles
OC(/C=C\C(O)=O)=O.CCC1=C2C(N=C(C3=C(N4C[C@H](CC4)N(C)C)N=CC=C3)OC2=O)=CC(OC)=C1
Molecular Formula
C26H30N4O7
Molecular Weight
510.54
References & Citations
[1]In vivo efficacy of KRP-109, a novel elastase inhibitor, in a murine model of severe pneumococcal pneumonia
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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