SI-W052

• Description :

  SI-W052 is an orally active, brain-penetrant and selective small-molecule inhibitor targeting mTOR and TEX264. SI-W052 activates autophagy by inhibiting mTOR phosphorylation and enhances TEX264 expression to promote ER turnover, suppressing LPS-induced release of inflammatory factors (TNF-α, IL-6) . SI-W052 is promising for research of Alzheimer’s disease (AD) -associated neuroinflammation[1].

• UNSPSC :

  12352005

• Target :

  Autophagy; Interleukin Related; mTOR

• Related Pathways :

  Autophagy; Immunology/Inflammation; PI3K/Akt/mTOR

• Field of Research :

  Inflammation/Immunology; Neurological Disease

• Purity :

  98.0

• Smiles :

  O=S(N(C)CC1=CC=CC=C1)(C2=C(Cl)C=C(NCC3=CC=CO3)C(C(O)=O)=C2)=O

• Molecular Formula :

  C20H19ClN2O5S

• Molecular Weight :

  434.89

• References & Citations :

  [1]Wang Z, et al. Anti-Inflammatory Anthranilate Analogue Enhances Autophagy through mTOR and Promotes ER-Turnover through TEX264 during Alzheimer-Associated Neuroinflammation. ACS Chem Neurosci. 2022 Feb 2;13 (3) :406-422.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  IL-6

• CAS Number :

  [2572552-60-2]