SI-W052

CAT: 0804-HY-174066-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-174066-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SI-W052 is an orally active, brain-penetrant and selective small-molecule inhibitor targeting mTOR and TEX264. SI-W052 activates autophagy by inhibiting mTOR phosphorylation and enhances TEX264 expression to promote ER turnover, suppressing LPS-induced release of inflammatory factors (TNF-α, IL-6) . SI-W052 is promising for research of Alzheimer’s disease (AD) -associated neuroinflammation[1].
CAS Number
[2572552-60-2]
UNSPSC
12352005
Target
Autophagy; Interleukin Related; mTOR
Related Pathways
Autophagy; Immunology/Inflammation; PI3K/Akt/mTOR
Field of Research
Inflammation/Immunology; Neurological Disease
Purity
98.0
Smiles
O=S(N(C)CC1=CC=CC=C1)(C2=C(Cl)C=C(NCC3=CC=CO3)C(C(O)=O)=C2)=O
Molecular Formula
C20H19ClN2O5S
Molecular Weight
434.89
References & Citations
[1]Wang Z, et al. Anti-Inflammatory Anthranilate Analogue Enhances Autophagy through mTOR and Promotes ER-Turnover through TEX264 during Alzheimer-Associated Neuroinflammation. ACS Chem Neurosci. 2022 Feb 2;13 (3) :406-422.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-6

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