SI-113

• Product Name Alternative:

  (+)-Bicuculline (methobromide); d-Bicuculline (methobromide)

• UNSPSC Description:

  SI-113 is a SGK1 inhibitor, with an IC50 of 600 nM. SI113 induces autophagy[1][2].

• Target Antigen:

  SGK

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/si-113.html

• Purity:

  98.02

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  OCCNC1=NC(NCCC2=CC=CC=C2)=C3C(N(/C=C/C4=CC=CC=C4)N=C3)=N1

• Molecular Weight:

  400.48

• References & Citations:

  [1]Marco Radi , et al. A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: from in silico screening to cyclodextrin formulation. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5579-83.|[2]Silvia Matteoni, et al. The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells. J Exp Clin Cancer Res. 2019 May 17;38(1):202.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1392816-46-4