SI-113

CAT: 0804-HY-117357-01Size: 5 mgDry Ice: NoHazardous: No

CAT#:0804-HY-117357-01Size:5 mg

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Description

SI-113 is a SGK1 inhibitor, with an IC50 of 600 nM. SI113 induces autophagy[1][2].

CAS Number

[1392816-46-4]

Product Name Alternative

(+)-Bicuculline (methobromide); d-Bicuculline (methobromide)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

SGK

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/si-113.html

Purity

98.02

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

OCCNC1=NC(NCCC2=CC=CC=C2)=C3C(N(/C=C/C4=CC=CC=C4)N=C3)=N1

Molecular Formula

C23H24N6O

Molecular Weight

400.48

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Marco Radi , et al. A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: from in silico screening to cyclodextrin formulation. Bioorg Med Chem Lett. 2012 Sep 1;22 (17) :5579-83.|[2]Silvia Matteoni, et al. The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells. J Exp Clin Cancer Res. 2019 May 17;38 (1) :202.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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HY-160554-01	C12-113
HY-153737-01	113-N16B
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Catalog	Name
BA8347-25	SI-113
MBS5779125	A 113
MBS9631192-01	SI Antibody
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MF-0015962-01	SI-2
MDP0613	Α-Conotoxin SI
DF15904-BP	SI Peptide
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MF-0139388-01	FAUC-113
MF-0054032-01	113-N16B

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