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2-PPA

CAT: 0804-HY-33878-03Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-33878-03Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
2-PPA is a selective inhibitor of TMEM175 (IC50=32 μM) with activity in modulating lysosomal function. Acute inhibition of TMEM175 by 2-PPA increases lysosomal macromolecular catabolism, thereby accelerating macrophage and other digestive processes. 2-PPA can be used in the study of Parkinson's disease[1].
CAS Number
21203-86-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/2-ppa.html
Purity
99.98
Solubility
DMSO : ≥ 100 mg/mL
Smiles
NC1=CC(C2=CC=CC=C2)=NC=C1
Molecular Formula
C11H10N2
Molecular Weight
170.22
Precautions
H302, H315, H319, H335
References & Citations
[1]SeCheol, et al. "Discovery of Selective Inhibitors for the Lysosomal Parkinson’s Disease Channel TMEM175." Journal of the American Chemical Society (2024) .
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

2-Phenylpyridin-4-amine
CAS Number21203-86-1
PubChem CID2762833
IUPAC Name2-phenylpyridin-4-amine
Molecular FormulaC11H10N2
Molecular Weight170.21
XLogP2.1
Topological Polar Surface Area38.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count13
Formal Charge0
Complexity152
SMILES
C1=CC=C(C=C1)C2=NC=CC(=C2)N
InChI
InChI=1S/C11H10N2/c12-10-6-7-13-11(8-10)9-4-2-1-3-5-9/h1-8H,(H2,12,13)
InChIKey
CHVKPWIABFICLK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-Phenylpyridin-4-amine
CAS: 21203-86-1
CID: 2762833
Formula: C11H10N2
MW: 170.21
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight170.21
XLogP32.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass170.084398327
Monoisotopic Mass170.084398327
Topological Polar Surface Area38.9 Ų
Heavy Atom Count13
Formal Charge0
Complexity152
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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