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PPA-037 (TFA)

CAT: 0804-HY-171787A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-171787A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PPA-037 TFA is an orally active, highly potent and selective inhibitor of cyclin-dependent kinase 12 (CDK12) . PPA-037 TFA induces the degradation of cyclin K (Cyclin K), enhancing antiproliferative effects on tumor cells. PPA-037 TFA is promising for research of cancers[1].
UNSPSC
12352005
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Purity
99.42
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
OC(C(F)(F)F)=O.C1(CNC2=CC(N[C@H]3CCNC3)=NC4=C(C5CC5)C=NN24)=CC=C(C6=CC=CC=N6)C=C1
Molecular Formula
C27H28F3N7O2
Molecular Weight
539.55
References & Citations
[1]Edward AINSCOW, et al. Substituted pyrazolo[1,5-a]pyrimidine-7-amine compounds as cdk inhibitors and their therapeutic use. WO2022263604A1. 2022-12-22
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK12

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