PPA-037

• Description:

  PPA-037 is an orally active, highly potent and selective inhibitor of cyclin-dependent kinase 12 (CDK12) . PPA-037 induces the degradation of cyclin K (Cyclin K), enhancing antiproliferative effects on tumor cells. PPA-037 is promising for research of cancers[1].

• UNSPSC:

  12352005

• Target:

  CDK

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Smiles:

  C1(CNC2=CC(N[C@H]3CCNC3)=NC4=C(C5CC5)C=NN24)=CC=C(C6=CC=CC=N6)C=C1

• Molecular Formula:

  C25H27N7

• Molecular Weight:

  425.53

• References & Citations:

  [1]Edward AINSCOW, et al. Substituted pyrazolo[1,5-a]pyrimidine-7-amine compounds as cdk inhibitors and their therapeutic use. WO2022263604A1. 2022-12-22

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CDK12

• CAS Number:

  [2883700-83-0]