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2',3'-cGAMP-C2-PPA

CAT: 0804-HY-141662Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-141662Size:1 Each
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Description
2’,3’-cGAMP-C2-PPA is a cyclic dinucleotide interferon gene-stimulating protein (STING) agonist. 2’,3’-cGAMP-C2-PPA is a drug conjugated conjugate used to target antibody-drug conjugated conjugate (ADC) for the treatment of cancer. 2’,3’-cGAMP-C2-PPA can be used in the study of immune and tumor-related diseases[1][2][3].
CAS Number
2586047-11-0
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC; STING
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/2-3-cgamp-c2-ppa.html
Solubility
10 mM in DMSO
Smiles
OC(CCC(C)SSCC[C@H]1[C@]2([H])[C@@](N3C4=C(C(N=C(N4)N)=O)N=C3)([H])O[C@]1([H])COP(O)(O[C@]5([H])[C@@](O[C@](N6C7=NC=NC(N)=C7N=C6)([H])[C@@H]5O)([H])COP(O)(O2)=O)=O)=O
Molecular Formula
C27H36N10O14P2S2
Molecular Weight
850.71
References & Citations
[1]Chen Z, et, al. Antibody-sting agonist conjugates and their use in immunotherapy. US20210015941A1.|[2]Stazzoni S, et al. Novel Poxin Stable cGAMP-Derivatives Are Remarkable STING Agonists. Angew Chem Int Ed Engl. 2022 Oct 4;61 (40) :e202207175.|[3]Zhang X, et al GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 2013 Jul 25;51 (2) :226-35
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported

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