2',3'-cGAMP-C2-PPA

2',3'-cGAMP-C2-PPA

• CAS Number: 2586047-11-0
• UNSPSC Description: 2’,3’-cGAMP-C2-PPA is a cyclic dinucleotide interferon gene-stimulating protein (STING) agonist. 2’,3’-cGAMP-C2-PPA is a drug conjugated conjugate used to target antibody-drug conjugated conjugate (ADC) for the treatment of cancer. 2’,3’-cGAMP-C2-PPA can be used in the study of immune and tumor-related diseases[1][2][3].
• Target Antigen: Drug-Linker Conjugates for ADC; STING
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related;Immunology/Inflammation
• Applications: Cancer-programmed cell death
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/2-3-cgamp-c2-ppa.html
• Solubility: 10 mM in DMSO
• Smiles: OC(CCC(C)SSCC[C@H]1[C@]2([H])[C@@](N3C4=C(C(N=C(N4)N)=O)N=C3)([H])O[C@]1([H])COP(O)(O[C@]5([H])[C@@](O[C@](N6C7=NC=NC(N)=C7N=C6)([H])[C@@H]5O)([H])COP(O)(O2)=O)=O)=O
• Molecular Weight: 850.71
• References & Citations: [1]Chen Z, et, al. Antibody-sting agonist conjugates and their use in immunotherapy. US20210015941A1.|[2]Stazzoni S, et al. Novel Poxin Stable cGAMP-Derivatives Are Remarkable STING Agonists. Angew Chem Int Ed Engl. 2022 Oct 4;61(40):e202207175.|[3]Zhang X, et al GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 2013 Jul 25;51(2):226-35
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported