(+) -ITD-1

• Description:

  (+) -ITD-1 is an inhibitor for TGF-β, that inhibits the TGF-β2 with an IC50 of 0.46 μM. (+) -ITD-1 promotes the degradation of TGF-b type II receptor (TGFBR2) and the differentiation of cardiomyocyte, and inhibits the mesoderm formation in the early differentiation stage of mouse embryonic stem cells (mESCs) [1].

• UNSPSC:

  12352005

• Target:

  TGF-beta/Smad; TGF-β Receptor

• Type:

  Reference compound

• Related Pathways:

  Stem Cell/Wnt; TGF-beta/Smad

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/plus-itd-1.html

• Smiles:

  O=C (C ([C@H] (C1=CC=C (C2=CC=CC=C2) C=C1) C (C (C3) =O) =C (CC3 (C) C) N4) =C4C) OCC

• Molecular Formula:

  C27H29NO3

• Molecular Weight:

  415.52

• References & Citations:

  [1]Willems E, et al., Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012 Aug 3;11 (2) :242-52.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1409968-46-2