(+) -ITD-1

• Description :

  (+) -ITD-1 is an inhibitor for TGF-β, that inhibits the TGF-β2 with an IC50 of 0.46 μM. (+) -ITD-1 promotes the degradation of TGF-b type II receptor (TGFBR2) and the differentiation of cardiomyocyte, and inhibits the mesoderm formation in the early differentiation stage of mouse embryonic stem cells (mESCs) [1].

• UNSPSC :

  12352005

• Target :

  TGF-beta/Smad; TGF-β Receptor

• Type :

  Reference compound

• Related Pathways :

  Stem Cell/Wnt; TGF-beta/Smad

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/plus-itd-1.html

• Smiles :

  O=C(C([C@H](C1=CC=C(C2=CC=CC=C2)C=C1)C(C(C3)=O)=C(CC3(C)C)N4)=C4C)OCC

• Molecular Formula :

  C27H29NO3

• Molecular Weight :

  415.52

• References & Citations :

  [1]Willems E, et al., Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012 Aug 3;11 (2) :242-52.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1409968-46-2]