(+) -ITD-1

CAT: 0804-HY-137063Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-137063Size:1 Each
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Description
(+) -ITD-1 is an inhibitor for TGF-β, that inhibits the TGF-β2 with an IC50 of 0.46 μM. (+) -ITD-1 promotes the degradation of TGF-b type II receptor (TGFBR2) and the differentiation of cardiomyocyte, and inhibits the mesoderm formation in the early differentiation stage of mouse embryonic stem cells (mESCs) [1].
CAS Number
[1409968-46-2]
UNSPSC
12352005
Target
TGF-beta/Smad; TGF-β Receptor
Type
Reference compound
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/plus-itd-1.html
Smiles
O=C(C([C@H](C1=CC=C(C2=CC=CC=C2)C=C1)C(C(C3)=O)=C(CC3(C)C)N4)=C4C)OCC
Molecular Formula
C27H29NO3
Molecular Weight
415.52
References & Citations
[1]Willems E, et al., Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012 Aug 3;11 (2) :242-52.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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