SP-100030

• Description :

  SP-100030 is a potent NF-κB and activator protein-1 (AP-1) double inhibitor (IC50s=50 and 50 nM, respectively) . SP-100030 inhibits IL-2, IL-8, and TNF-alpha production in Jurkat and other T cell lines. SP-100030 decreases murine collagen-induced arthritis (CIA) [1][2].

• UNSPSC :

  12352005

• Target :

  NF-κB

• Type :

  Reference compound

• Related Pathways :

  NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/sp-100030.html

• Purity :

  99.57

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  FC(F)(F)C1=CC(C(F)(F)F)=CC(NC(C2=CN=C(Cl)N=C2C(F)(F)F)=O)=C1

• Molecular Formula :

  C14H5ClF9N3O

• Molecular Weight :

  437.65

• References & Citations :

  [1]Sullivan RW, et al. 2-Chloro-4- (trifluoromethyl) pyrimidine-5-N- (3',5'- bis (trifluoromethyl) phenyl) -carboxamide: a potent inhibitor of NF-kappa B- and AP-1-mediated gene expression identified using solution-phase combinatorial chemistry. J Med Chem. 1998;41 (4) :413-419.|[2]Gerlag DM, et al. The effect of a T cell-specific NF-kappa B inhibitor on in vitro cytokine production and collagen-induced arthritis. J Immunol. 2000;165 (3) :1652-1658.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [154563-54-9]