SP-471P

CAT: 0804-HY-144645-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-144645-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

SP-471P is a potent dengue virus (DENV) protease inhibitor with EC50s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM for DENV1, DENV2, DENV3 and DENV4, respectively and CC50 value over 100 μM. SP-471P can reduce DENV viral RNA synthesis[1].

CAS Number

2768011-36-3

UNSPSC

12352005

Target

Dengue Virus; DNA/RNA Synthesis; Flavivirus; Virus Protease

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sp-471p.html

Purity

99.46

Solubility

10 mM in DMSO

Smiles

N/C(C1=CC=CC(C2=CC=C3C(C4=C(N3CC5=CC=CC(Br)=C5)C=CC(C6=CC=CC(/C(N)=N/O)=C6)=C4)=C2)=C1)=N\O

Molecular Formula

C33H26BrN5O2

Molecular Weight

604.50

References & Citations

[1]Swarbrick C, Zogali V, Chan KWK, et al. Amidoxime prodrugs convert to potent cell-active multimodal inhibitors of the dengue virus protease. Eur J Med Chem. 2021;224:113695.

Shipping Conditions

Room Temperature

Storage Conditions

Store at room temperature, keep dry and cool

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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