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SP-141

CAT: 0804-HY-110182-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110182-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SP-141 is a specific inhibitor of MDM2. SP-141 promotes MDM2 auto-ubiquitination and degradation. SP-141 might be used for the research of pancreatic cancer and breast cancer cells[1].
CAS Number
1253491-42-7
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sp-141.html
Purity
99.94
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
COC1=CC2=C(NC3=C2C=CN=C3C4=C5C=CC=CC5=CC=C4)C=C1
Molecular Formula
C22H16N2O
Molecular Weight
324.38
Precautions
H315, H319, H335
References & Citations
[1]Wei Wang , et al. Identification of a New Class of MDM2 Inhibitor That Inhibits Growth of Orthotopic Pancreatic Tumors in Mice. Gastroenterology. 2014 Oct;147 (4) :893-902.e2.|[2]Wei Wang, et al. The Pyrido[b]indole MDM2 Inhibitor SP-141 Exerts Potent Therapeutic Effects in Breast Cancer Models. Nat Commun. 2014 Oct 1;5:5086.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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