2B- (SP)

• Description:

  2B- (SP) is a eIF2B-based substrate for glycogen synthase kinase-3 (GSK-3) . 2B- (SP) is readily phosphorylated by both the α and β isoforms of GSK-3[1].

• UNSPSC:

  12352209

• Target:

  GSK-3

• Type:

  Peptides

• Related Pathways:

  PI3K/Akt/mTOR; Stem Cell/Wnt

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/2b-sp.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N=C(N)NCCC[C@H](N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(NCC(N[C@@H](COP(O)(O)=O)C(N1[C@@H](CCC1)C(N[C@@H](CCC(N)=O)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

• Molecular Formula:

  C71H123N26O29P

• Molecular Weight:

  1835.87

• References & Citations:

  [1]G I Welsh, et al. Peptide substrates suitable for assaying glycogen synthase kinase-3 in crude cell extracts.Anal Biochem. 1997 Jan 1;244 (1) :16-21.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  GSK-3α; GSK-3β

• CAS Number:

  [186901-17-7]