KS-58

• Target:

  Ras

• Related Pathways:

  MAPK|||GPCR/G Protein

• Bioactivity:

  KS-58 is a derivative of KRpep-2d. It acts as an inhibitory peptide for K-Ras (G12D), selectively binding to K-Ras. KS-58 is capable of penetrating cells and interrupts the interaction between intracellular Ras and effector proteins. It inhibits the proliferation of tumor cells and exhibits antitumor activity.

• Smiles:

  C (C=1C=2C (NC1) =CC=CC2) [C@@H]3NC (=O) [C@]4 (N (C (=O) [C@H] (CC (O) =O) NC (=O) [C@H] (CC5=CC=C (F) C=C5) NC (=O) [C@H] (CO) NC (=O) [C@H] (CCCCCCC) NC (=O) [C@@]6 (CSCCCSC[C@@] (NC3=O) (C (=O) NCCC (=O) N7[C@] (C (=O) N[C@@H] (CCCC) C (=O) N6) (CCC7) [H]) [H]) [H]) CCC4) [H]

• Molecular Formula:

  C64H89FN12O14S2

• Molecular Weight:

  1333.59

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2549046-46-8