KS-58

• Target :

  Ras

• Related Pathways :

  MAPK|||GPCR/G Protein

• Bioactivity :

  KS-58 is a derivative of KRpep-2d. It acts as an inhibitory peptide for K-Ras (G12D), selectively binding to K-Ras. KS-58 is capable of penetrating cells and interrupts the interaction between intracellular Ras and effector proteins. It inhibits the proliferation of tumor cells and exhibits antitumor activity.

• Smiles :

  C(C=1C=2C(NC1)=CC=CC2)[C@@H]3NC(=O)[C@]4(N(C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC5=CC=C(F)C=C5)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCCCC)NC(=O)[C@@]6(CSCCCSC[C@@](NC3=O)(C(=O)NCCC(=O)N7[C@](C(=O)N[C@@H](CCCC)C(=O)N6)(CCC7)[H])[H])[H])CCC4)[H]

• Molecular Formula :

  C64H89FN12O14S2

• Molecular Weight :

  1333.59

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2549046-46-8