KS 501

• Description :

  KS 501 is a potent and selective calmodulin inhibitor. KS 501 inhibits the activation of calmodulin kinase I and II, but has less effect against cyclic adenosine 3’,5’-monophosphate (cyclic AMP) -sensitive kinase. KS 501 inhibits the enzyme through interfering with calmodulin activation rather than through a direct effect on the enzyme. KS 501 can be used for the study of leukemia[1].

• CAS Number :

  [120634-86-8]

• UNSPSC :

  12352005

• Target :

  Calmodulin

• Related Pathways :

  Membrane Transporter/Ion Channel

• Field of Research :

  Cancer

• Smiles :

  O[C@@H]1[C@H](O)[C@@H](OC2=C(C(CCCCCCC)=CC(O)=C2)C(OC3=CC(CCCCCCC)=CC(O)=C3)=O)O[C@@]1([C@H](O)CO)[H]

• Molecular Formula :

  C33H48O10

• Molecular Weight :

  604.73

• References & Citations :

  [1]Hait WN, et al. Effects of KS-501, KS-502 and their enantiomers on calmodulin-sensitive enzyme activity and cellular proliferation. Biochem Pharmacol. 1995 Jun 29;50 (1) :69-74.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported