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ROCK2-IN-9

CAT: 0804-HY-162798Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162798Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ROCK2-IN-9 (compound 7u) is a selective ROCK2 inhibitor (IC50=36.8 nM) with anticancer activity. ROCK2-IN-9 inhibits cancer cell migration and invasion by regulating multiple cellular activities of the actin cytoskeleton. ROCK2-IN-9 can be used in breast cancer research[1].
UNSPSC
12352005
Target
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rock2-in-9.html
Smiles
CC(C=C1)=CC=C1CN(CC2)CCN2C3=NC4=C(C(OCC)=O)C=NN4C(NC5=CC=C(NN=C6)C6=C5)=C3
Molecular Formula
C28H30N8O2
Molecular Weight
510.59
References & Citations
[1]Zhi Cao, et al. "Discovery of novel pyrazolo [1, 5-a] pyrimidine derivatives as selective ROCK2 inhibitors with anti-breast cancer migration and invasion activities." Bioorganic Chemistry (2024) : 107675.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ROCK2

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