ROCK2-IN-8

• UNSPSC Description:

  ROCK2-IN-8 (Compound 1) is an orally active ROCK2 inhibitor, with an IC50 of 7.2 nM. ROCK2-IN-8 can be used for the research of aqueous humor outflow in porcine eyes and myosin light chain phosphorylation[1].

• Target Antigen:

  ROCK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Cytoskeleton;Stem Cell/Wnt;TGF-beta/Smad

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/rock2-in-8.html

• Purity:

  99.38

• Solubility:

  DMSO : 5 mg/mL (ultrasonic)

• Smiles:

  O=C(C1OC2=C(OC1)C=CC=C2)NC3=NC(C4=CC=NC=C4)=CS3

• Molecular Weight:

  339.37

• References & Citations:

  [1]Feng Y, et al. Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J Med Chem. 2008 Nov 13;51(21):6642-5.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  681173-76-2