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ROCK2-IN-12

CAT: 0804-HY-178821Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178821Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ROCK2-IN-12 (Compound A25) is a selective ROCK2 inhibitor with an IC50 of 7.0 nM for ROCK2 over ROCK1. ROCK2-IN-12 has potent antifibrotic effects via the TGF-β/Smad and ROCK2/STAT3 signaling pathways. ROCK2-IN-12 significantly reduces collagen deposition and reverses fibrotic progression in Bleomycin -induced pulmonary fibrosis (PF) mouse models. ROCK2-IN-12 can be used for lung diseases like pulmonary fibrosis research[1].
CAS Number
3086603-12-2
UNSPSC
12352005
Target
ROCK; STAT; TGF-beta/Smad
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; JAK/STAT Signaling; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Inflammation/Immunology
Smiles
FC(C=C1)=CC=C1CNCC2=NC(C3=CN=C4C=CC(NC5=CC6=C(C=C5)NN=C6)=NN43)=NO2
Molecular Formula
C23H18FN9O
Molecular Weight
455.45
References & Citations
[1]Cao Z, et al. Identification of Novel Imidazo[1,2-b]pyridazine Derivatives as Selective ROCK2 Inhibitors for the Treatment of Pulmonary Fibrosis. J Med Chem. 2025 Oct 23;68 (20) :21892-21916.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ROCK1; ROCK2; STAT3

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