ROCK2-IN-7
CAT:
804-HY-149700
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
ROCK2-IN-7
- CAS Number: 3000541-95-4
- UNSPSC Description: ROCK2-IN-7 is a kinase inhibitor targeting to ROCK2. ROCK2-IN-7 inhibits ROCK2/pSTAT3 Signaling. ROCK2-IN-7 suppresses systemic immunity activation and attenuates inflammation in psoriasis model[1].
- Target Antigen: MMP; ROCK; STAT
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Cytoskeleton;JAK/STAT Signaling;Metabolic Enzyme/Protease;Stem Cell/Wnt;TGF-beta/Smad
- Applications: Metabolism-protein/nucleotide metabolism
- Field of Research: Others
- Assay Protocol: https://www.medchemexpress.com/rock2-in-7.html
- Solubility: 10 mM in DMSO
- Smiles: O=C1N(C=C(C(C)=C1)F)C2=CC(CN[C@H]3CCC[C@@H](C3)NC4=CC=C5NN=CC5=C4)=CC=C2
- Molecular Weight: 445.53
- References & Citations: [1]Huang, Yun, et al. "Design, Synthesis, and Biological Evaluation of an Orally Bioavailable, Potent, and Selective ROCK2 Inhibitor for Psoriasis Treatment." Journal of Medicinal Chemistry (2023)
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported