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ROCK2-IN-10

CAT: 0804-HY-175843Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175843Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ROCK2-IN-10 is a potent and selective ROCK2 inhibitor (IC50 = 0.020 μM) with 41-fold selectivity over isoform ROCK1. ROCK2-IN-10 inhibits metastasis by disrupting the cytoskeleton, independent of proliferative suppression. ROCK2-IN-10 shows superior inhibitory potency against cancer cell metastasis, which closely related to the suppression of STAT3 phosphorylation. ROCK2-IN-10 can be used for breast cancer metastasis research[1].
UNSPSC
12352005
Target
ROCK; STAT
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; JAK/STAT Signaling; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CC(C=C1)=CC=C1NC(OC[C@H](CCC2)N2C3=NC(NC4=CC5=C(C=C4)NN=C5)=CC=C3NC(CNC6CCCC6)=O)=O
Molecular Formula
C32H38N8O3
Molecular Weight
582.70
References & Citations
[1]Zhang J, et al. Design and synthesis of ROCK2-selective inhibitors bearing 6-indazolamino-2-pyrrolidinylpyridine for the treatment of breast cancer metastasis. Bioorg Chem. 2025 Sep;164:108862.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ROCK1; ROCK2

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