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ROCK2-IN-13

CAT: 0804-HY-179498Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179498Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ROCK2-IN-13 is a selective ROCK2 inhibitor. ROCK2-IN-13 reduces nuclear expression by disrupting the interaction of ROCK2 with transcriptional co activators p300> and PGC 1α, repressing oncogenic transcription. ROCK2-IN-13 activates FOXO1 driven PTEN expression, leading to suppression of the PI3K/Akt pathway, induction of G2/M cell cycle arrest, and promotion of apoptosis. ROCK2-IN-13 ablates the nuclear transcriptional function of ROCK2 that sustains oncogenic signaling and restores the tumor suppressive PTEN/FOXO1 axis. ROCK2-IN-13 can be used for prostate cancer reseach[1].
UNSPSC
12352005
Target
Akt; Apoptosis; Epigenetic Reader Domain; FOXO; PI3K; PTEN; ROCK
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
N#CC1=CC=C(C=C1C(F)(F)F)NC(NC2=CC=C3C=NC=CC3=C2)=S
Molecular Formula
C18H11F3N4S
Molecular Weight
372.37
References & Citations
[1]Lee J, et al. Inhibition of nuclear ROCK2 by a novel thiourea derivative induces potent antitumor effects through PTEN/FOXO1 pathway restoration in prostate cancer. Bioorg Chem. 2025 Dec;167:109211.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt; FOXO1; PI3K; ROCK2

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