ROCK2-IN-5

• Description:

  ROCK2-IN-5 (compound 1d) is a hybrid compound containing structural fragments of the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids. ROCK2-IN-5 has good multitarget profile and good tolerability. ROCK2-IN-5 has the potential for thr research of Amyotrophic lateral sclerosis (ALS) with a SOD1 mutation[1].

• UNSPSC:

  12352005

• Target:

  ROCK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/rock2-in-5.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(CCC1=CC(O)=C(C=C1)O)N2CCCN(S(C3=C4C(C=NC=C4)=CC=C3)(=O)=O)CC2

• Molecular Formula:

  C23H25N3O5S

• Molecular Weight:

  455.53

• References & Citations:

  [1]Martín-Cámara O, et al. Multitarget Hybrid Fasudil Derivatives as a New Approach to the Potential Treatment of Amyotrophic Lateral Sclerosis. J Med Chem. 2022;65 (3) :1867-1882.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  ROCK2

• CAS Number:

  [3031515-48-4]