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ROCK2-IN-5

CAT: 0804-HY-145294Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145294Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ROCK2-IN-5 (compound 1d) is a hybrid compound containing structural fragments of the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids. ROCK2-IN-5 has good multitarget profile and good tolerability. ROCK2-IN-5 has the potential for thr research of Amyotrophic lateral sclerosis (ALS) with a SOD1 mutation[1].
CAS Number
3031515-48-4
UNSPSC
12352005
Target
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rock2-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C(CCC1=CC(O)=C(C=C1)O)N2CCCN(S(C3=C4C(C=NC=C4)=CC=C3)(=O)=O)CC2
Molecular Formula
C23H25N3O5S
Molecular Weight
455.53
References & Citations
[1]Martín-Cámara O, et al. Multitarget Hybrid Fasudil Derivatives as a New Approach to the Potential Treatment of Amyotrophic Lateral Sclerosis. J Med Chem. 2022;65 (3) :1867-1882.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ROCK2

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