NHC-diphosphate

• Description:

  NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a diphosphate form[1]. NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV) [1].

• UNSPSC:

  12352005

• Target:

  CHIKV; Endogenous Metabolite; Enterovirus; HCV; SARS-CoV; Topoisomerase

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/nhc-diphosphate.html

• Purity:

  98.80

• Solubility:

  H2O : 160 mg/mL (ultrasonic)

• Smiles:

  O[C@H] ([C@@H]1O) [C@@] (N (C=C/C2=N\O) C (N2) =O) ([H]) O[C@@H]1CO[P] (O[P] (O) (O) =O) (O) =O

• Molecular Formula:

  C9H15N3O12P2

• Molecular Weight:

  419.18

• References & Citations:

  [1]Brenda I Hernandez-Santiago, et al. Metabolism of the anti-hepatitis C virus nucleoside beta-D-N4-hydroxycytidine in different liver cells. Antimicrob Agents Chemother. 2004 Dec;48 (12) :4636-42|[2]Maryam Ehteshami, et al. Characterization of β-d- N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  39023-73-9