NHC-triphosphate

• UNSPSC Description:

  NHC-triphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a triphosphate form[1]. NHC-triphosphate is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA[1][2].

• Target Antigen:

  Endogenous Metabolite; Enterovirus; HCV; SARS-CoV; Topoisomerase

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/nhc-triphosphate.html

• Purity:

  99.80

• Solubility:

  H2O : 160 mg/mL (ultrasonic)

• Smiles:

  O[C@H]1[C@H](N(C=C/C2=N/O)C(N2)=O)O[C@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)[C@H]1O

• Molecular Weight:

  499.16

• References & Citations:

  [1]Stuyver LJ,et al. Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.Antimicrob Agents Chemother. 2003 Jan;47(1):244-54.|[2]Maryam Ehteshami, et al. Characterization of β-d- N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus.ACS Bio Med Chem Au. October 24, 2022.|Commun Biol. 2022 Feb 22;5(1):154.|J Biol Chem. 2021 May 11;100770.|Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.|ACS Sens. 2022 May 27;7(5):1564-1571.|bioRxiv. 2021 Jul 21:2021.07.21.453274. |Nat Struct Mol Biol. 2021 Sep;28(9):740-746.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light, stored under nitrogen)

• Clinical Information:

  No Development Reported

• CAS Number:

  34973-27-8