Pt (II) -NHC complex 2C

• Description :

  Pt (II) -NHC Complex 2C (Platinum (II) -N-Heterocyclic Carbene complex 2C) (Compound 2C) is a platinum (II) complex based on N-heterocyclic carbene (NHC) . Pt (II) -NHC Complex 2C is an immunogenic cell death (ICD) inducer that can induce endoplasmic reticulum stress (ERS) in liver cancer cells and produce reactive oxygen species (ROS), ultimately leading to the release of damage-associated molecular patterns (DAMP) . Pt (II) -NHC Complex 2C blocks the cell cycle at the S phase and significantly induces cell apoptosis. Pt (II) -NHC Complex 2C shows anti-liver cancer potential in mouse models and activates immune cells in liver injury models.

• Product Name Alternative :

  Platinum (II) -N-heterocyclic carbene complex 2C

• UNSPSC :

  12352005

• Target :

  Apoptosis; ER-phagy; Reactive Oxygen Species (ROS)

• Related Pathways :

  Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Field of Research :

  Cancer

• Smiles :

  I[Pt](I)([N]1=CC=CC=C1)=C(N2CC)N(CC)C(C3=CC=C(F)C=C3)=C2C4=CC=C(F)C=C4

• Molecular Formula :

  C24H23F2I2N3Pt

• Molecular Weight :

  840.35

• References & Citations :

  [1]Bian M, et al. Pt (II) -NHC Complex Induces ROS-ERS-Related DAMP Balance to Harness Immunogenic Cell Death in Hepatocellular Carcinoma. J Med Chem. 2022 Feb 10;65 (3) :1848-1866.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3035433-94-1]