Pt (II) -NHC complex 2C

CAT: 0804-HY-175048Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175048Size:1 Each
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Description
Pt (II) -NHC Complex 2C (Platinum (II) -N-Heterocyclic Carbene complex 2C) (Compound 2C) is a platinum (II) complex based on N-heterocyclic carbene (NHC) . Pt (II) -NHC Complex 2C is an immunogenic cell death (ICD) inducer that can induce endoplasmic reticulum stress (ERS) in liver cancer cells and produce reactive oxygen species (ROS), ultimately leading to the release of damage-associated molecular patterns (DAMP) . Pt (II) -NHC Complex 2C blocks the cell cycle at the S phase and significantly induces cell apoptosis. Pt (II) -NHC Complex 2C shows anti-liver cancer potential in mouse models and activates immune cells in liver injury models.
CAS Number
[3035433-94-1]
Product Name Alternative
Platinum (II) -N-heterocyclic carbene complex 2C
UNSPSC
12352005
Target
Apoptosis; ER-phagy; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
I[Pt](I)([N]1=CC=CC=C1)=C(N2CC)N(CC)C(C3=CC=C(F)C=C3)=C2C4=CC=C(F)C=C4
Molecular Formula
C24H23F2I2N3Pt
Molecular Weight
840.35
References & Citations
[1]Bian M, et al. Pt (II) -NHC Complex Induces ROS-ERS-Related DAMP Balance to Harness Immunogenic Cell Death in Hepatocellular Carcinoma. J Med Chem. 2022 Feb 10;65 (3) :1848-1866.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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