NHC-diphosphate

• UNSPSC Description:

  NHC-diphosphate is an active phosphorylated?intracellular metabolite?of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a diphosphate form[1]. NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication?of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV)? and hepatitis C virus?(HCV)[1].

• Target Antigen:

  Endogenous Metabolite; Enterovirus; HCV; SARS-CoV; Topoisomerase

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/nhc-diphosphate.html

• Smiles:

  O[C@H]([C@@H]1O)[C@@](N(C=C/C2=N\O)C(N2)=O)([H])O[C@@H]1CO[P](O[P](O)(O)=O)(O)=O

• Molecular Weight:

  419.18

• References & Citations:

  [1]Brenda I Hernandez-Santiago, et al. Metabolism of the anti-hepatitis C virus nucleoside beta-D-N4-hydroxycytidine in different liver cells. Antimicrob Agents Chemother. 2004 Dec;48(12):4636-42|[2]Maryam Ehteshami, et al. Characterization of β-d- N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus.

• Shipping Conditions:

  Blue Ice

• CAS Number:

  39023-73-9