NHC-diphosphate (triammonium)

• UNSPSC Description:

  NHC-diphosphate triammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a diphosphate form[1]. NHC-diphosphate triammonium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA[1][2].

• Target Antigen:

  Endogenous Metabolite; Enterovirus; HCV; SARS-CoV; Topoisomerase

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/nhc-diphosphate-triammonium.html

• Smiles:

  O[C@H]([C@@H]1O)[C@@](N(C=C/C2=N\O)C(N2)=O)([H])O[C@@H]1CO[P](O[P](O)(O)=O)(O)=O.N.N.N

• Molecular Weight:

  470.27

• References & Citations:

  [1]Stuyver LJ,et al. Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.Antimicrob Agents Chemother. 2003 Jan;47(1):244-54.|[2]Maryam Ehteshami, et al. Characterization of β-d- N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus.

• Shipping Conditions:

  Blue Ice