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NHC-triphosphate (tetrasodium)

CAT: 0804-HY-135867A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-135867A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NHC-triphosphate tetrasodium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form[1]. NHC-triphosphate tetrasodium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA[1][2].
UNSPSC
12352005
Target
CHIKV; Endogenous Metabolite; Enterovirus; HCV; Topoisomerase
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Purity
81.53
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@H](N(C=C/C2=N/O)C(N2)=O)O[C@H](COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)[C@H]1O
Molecular Formula
C9H12N3Na4O15P3
Molecular Weight
587.08
References & Citations
[1]Stuyver LJ, et al. Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.Antimicrob Agents Chemother. 2003 Jan;47 (1) :244-54.|[2]Maryam Ehteshami, et al. Characterization of β-d- N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
ACS Sens. 2022 May 27;7 (5) :1564-1571.|ACS Bio Med Chem Au. 2022 Oct 24;2 (6) :565-585.|Commun Biol. 2022 Feb 22;5 (1) :154.|J Biol Chem. 2021 Jul;297 (1) :100770.|Nucleic Acids Res. 2021 Jan 8;49 (D1) :D1113-D1121.|bioRxiv. 2021 Jul 21:2021.07.21.453274. |J Control Release. 2025 Sep 18:387:114245.|Nat Struct Mol Biol. 2021 Sep;28 (9) :740-746.

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