Ac-ANW-AMC

CAT: 0804-HY-D1705-01Size: 500 µgDry Ice: NoHazardous: No

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CAT#:0804-HY-D1705-01Size:500 µg

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Description

Ac-ANW-AMC is a fluorogenic substrate for immunoproteasome. Ac-ANW-AMC can be used to measure β5i activity (Ex=345 nm, Em=445 nm) [1][2].

CAS Number

2357123-49-8

UNSPSC

12171500

Target

Proteasome

Type

Dye Reagents

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ac-anw-amc.html

Purity

99.40

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C1OC2=CC=C(C=C2C(C)=C1)NC([C@@H](NC([C@H](CC(N)=O)NC([C@H](C)NC(C)=O)=O)=O)CC3=CNC4=CC=CC=C34)=O

Molecular Formula

C30H32N6O7

Molecular Weight

588.61

References & Citations

[1]Winter, M.B., La Greca, F., Arastu-Kapur, S., et al. Immunoproteasome functions explained by divergence in cleavage specificity and regulation. eLife 6:e27364, (2017) . |[2]Sumin Kim, et al. Evaluation of Immunoproteasome-Specific Proteolytic Activity Using Fluorogenic Peptide Substrates. Immune Netw. 2022 Apr 15;22 (3) :e28.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light)

Scientific Category

Dye Reagents

Clinical Information

No Development Reported

Chemical Information

Ac-ANW-AMC

CAS Number	2357123-49-8
PubChem CID	165412519
IUPAC Name	(2S)-2-[[(2S)-2-acetamidopropanoyl]amino]-N-[(2S)-3-(1H-indol-3-yl)-1-[(4-methyl-2-oxochromen-6-yl)amino]-1-oxopropan-2-yl]butanediamide
Molecular Formula	C30H32N6O7
Molecular Weight	588.6
XLogP	0.4
Topological Polar Surface Area	202
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	11
Heavy Atom Count	43
Formal Charge	0
Complexity	1140

SMILES

CC1=CC(=O)OC2=C1C=C(C=C2)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](C)NC(=O)C

InChI

InChI=1S/C30H32N6O7/c1-15-10-27(39)43-25-9-8-19(12-21(15)25)34-29(41)23(11-18-14-32-22-7-5-4-6-20(18)22)36-30(42)24(13-26(31)38)35-28(40)16(2)33-17(3)37/h4-10,12,14,16,23-24,32H,11,13H2,1-3H3,(H2,31,38)(H,33,37)(H,34,41)(H,35,40)(H,36,42)/t16-,23-,24-/m0/s1

InChIKey

LMUIALVDZMMUMF-ZCWWJEROSA-N

Chemical Structure

2D Structure

CAS: 2357123-49-8

CID: 165412519

Formula: C30H32N6O7

MW: 588.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	588.6
XLogP3	0.4
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	11
Exact Mass	588.23324738
Monoisotopic Mass	588.23324738
Topological Polar Surface Area	202 Å²
Heavy Atom Count	43
Formal Charge	0
Complexity	1140
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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T37420-01	Ac-ANW-AMC
13455-AAT	(Ac-ANW) 2R110
T85587-01	Ac-QPKK (Ac) -AMC
GTR19144608-01	Ac-RYQK (Ac) -AMC
TP3791-01	Ac-RHKK (Ac) -AMC
BA4167-5.1	Ac-Lys-AMC
C8322-5	Ac-YEVD-AMC
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I-1830.0050	Ac-Ala-AMC
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Ac-ANW-AMC

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