Ac-PAL-AMC

CAT: 0804-HY-123052-01Size: 1 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-123052-01Size:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

Ac-PAL-AMC is a fluorogenic substrate specific for 20S proteasome LMP2/β1i activity[1].

CAS Number

1431362-79-6

UNSPSC

12352005

Target

Proteasome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ac-pal-amc.html

Purity

99.9

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C)C[C@@H](C(NC1=CC=C(C(O2)=C1)C(C)=CC2=O)=O)NC([C@H](C)NC([C@H]3N(C(C)=O)CCC3)=O)=O

Molecular Formula

C26H34N4O6

Molecular Weight

498.57

References & Citations

[1]Basler M, et al. Why the structure but not the activity of the immunoproteasome subunit low molecular mass polypeptide 2 rescues antigen presentation. J Immunol. 2012 Aug 15;189 (4) :1868-77.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

Ac-PAL-AMC

CAS Number	1431362-79-6
PubChem CID	137700547
IUPAC Name	(2S)-1-acetyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
Molecular Formula	C26H34N4O6
Molecular Weight	498.6
XLogP	1.9
Topological Polar Surface Area	134
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	8
Heavy Atom Count	36
Formal Charge	0
Complexity	916

SMILES

CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H]3CCCN3C(=O)C

InChI

InChI=1S/C26H34N4O6/c1-14(2)11-20(25(34)28-18-8-9-19-15(3)12-23(32)36-22(19)13-18)29-24(33)16(4)27-26(35)21-7-6-10-30(21)17(5)31/h8-9,12-14,16,20-21H,6-7,10-11H2,1-5H3,(H,27,35)(H,28,34)(H,29,33)/t16-,20-,21-/m0/s1

InChIKey

BWJPVHDZSJFFDM-NDXORKPFSA-N

Chemical Structure

2D Structure

CAS: 1431362-79-6

CID: 137700547

Formula: C26H34N4O6

MW: 498.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	498.6
XLogP3	1.9
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	8
Exact Mass	498.24783482
Monoisotopic Mass	498.24783482
Topological Polar Surface Area	134 Å²
Heavy Atom Count	36
Formal Charge	0
Complexity	916
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-P11213	Ac-RYQK (Ac) -AMC
HY-P11212	Ac-RHKK (Ac) -AMC
HY-P3364-01	Ac-QPKK (Ac) -AMC
HY-P11406	Ac-RSLK-AMC
HY-P10082	Ac-VETD-AMC
HY-P5378	Ac-KQKLR-AMC
HY-123051-01	Ac-WLA-AMC
HY-P4449	Ac-VRPR-AMC
HY-P2717-01	Ac-YVAD-AMC
HY-P10162	Ac-DMQD-AMC

Alternative Products

Catalog	Name
BA8292-5	Ac-PAL-AMC
13467-AAT	(Ac-PAL) 2R110
T85587-01	Ac-QPKK (Ac) -AMC
GTR19144608-01	Ac-RYQK (Ac) -AMC
TP3791-01	Ac-RHKK (Ac) -AMC
BA4167-5.1	Ac-Lys-AMC
C8322-5	Ac-YEVD-AMC
4028557.0050	Ac-Met-AMC
I-1830.0050	Ac-Ala-AMC
T36342-01	Ac-LEHD-AMC

Ac-PAL-AMC

Chemical Information

Related Products

Alternative Products

Popular Products