Ac-DMQD-AMC

• UNSPSC Description:

  Ac-DMQD-AMC is an inhibitor of caspase-3. Ac-DMQD-AMC is an aromatic amine using aminium-based coupling reagent HATU in the presence of 2,4,6-trimethylpyridine (TMP)[1].

• Target Antigen:

  Caspase

• Type:

  Peptides

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ac-dmqd-amc.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C1=CC=C(C=C1O2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC(O)=O)=O)CCSC)=O)CCC(N)=O)=O)CC(O)=O)=O)=CC2=O

• Molecular Weight:

  706.72

• References & Citations:

  [1]Przemysław Reszka, et al. Control of aspartate epimerization during the coupling of caspase specific tetrapeptides with aromatic amines by using N-[[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]-pyridin-1-yl]methylene]-N-methylmethanaminium hexafluorophosphate N-oxide (HATU) as a coupling reagent. Tetrahedron: Asymmetry. 2008, 19, 1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  355137-38-1