Ac-DMQD-AMC

Ac-DMQD-AMC

• CAS Number: 355137-38-1
• UNSPSC Description: Ac-DMQD-AMC is an inhibitor of caspase-3. Ac-DMQD-AMC is an aromatic amine using aminium-based coupling reagent HATU in the presence of 2,4,6-trimethylpyridine (TMP)[1].
• Target Antigen: Caspase
• Type: Peptides
• Related Pathways: Apoptosis
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ac-dmqd-amc.html
• Solubility: 10 mM in DMSO
• Smiles: CC(C1=CC=C(C=C1O2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC(O)=O)=O)CCSC)=O)CCC(N)=O)=O)CC(O)=O)=O)=CC2=O
• Molecular Weight: 706.72
• References & Citations: [1]Przemysław Reszka, et al. Control of aspartate epimerization during the coupling of caspase specific tetrapeptides with aromatic amines by using N-[[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]-pyridin-1-yl]methylene]-N-methylmethanaminium hexafluorophosphate N-oxide (HATU) as a coupling reagent. Tetrahedron: Asymmetry. 2008, 19, 1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported