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Ac-YVAD-AMC

CAT: 0804-HY-P2717-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P2717-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ac-YVAD-AMC is an inhibitor for caspase. Ac-YVAD-AMC inhibits bacteria-induced cell death of hypersensitive response (HR) cells[1].
CAS Number
149231-65-2
UNSPSC
12352209
Target
Caspase
Type
Peptides
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ac-yvad-amc.html
Purity
99.64
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CC(C1=CC=C(NC([C@H](CC(O)=O)NC([C@H](C)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CC2=CC=C(C=C2)O)=O)=O)=O)=O)C=C1O3)=CC3=O
Molecular Formula
C33H39N5O10
Molecular Weight
665.69
References & Citations
[1]del Pozo O, et al., Caspases and programmed cell death in the hypersensitive response of plants to pathogens. Curr Biol. 1998 Oct 8;8 (20) :1129-32.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

Ac-YVAD-AMC
CAS Number149231-65-2
PubChem CID4337
IUPAC Name3-[2-[[2-[[2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoylamino]-4-[(4-methyl-2-oxochromen-7-yl)amino]-4-oxobutanoic acid
Molecular FormulaC33H39N5O10
Molecular Weight665.7
XLogP1.3
Topological Polar Surface Area229
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count10
Rotatable Bond Count14
Heavy Atom Count48
Formal Charge0
Complexity1260
SMILES
CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C(C(C)C)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C
InChI
InChI=1S/C33H39N5O10/c1-16(2)29(38-32(46)24(35-19(5)39)13-20-6-9-22(40)10-7-20)33(47)34-18(4)30(44)37-25(15-27(41)42)31(45)36-21-8-11-23-17(3)12-28(43)48-26(23)14-21/h6-12,14,16,18,24-25,29,40H,13,15H2,1-5H3,(H,34,47)(H,35,39)(H,36,45)(H,37,44)(H,38,46)(H,41,42)
InChIKey
YGLOALWHJIANIH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ac-YVAD-AMC
CAS: 149231-65-2
CID: 4337
Formula: C33H39N5O10
MW: 665.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight665.7
XLogP31.3
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count10
Rotatable Bond Count14
Exact Mass665.26969246
Monoisotopic Mass665.26969246
Topological Polar Surface Area229 Ų
Heavy Atom Count48
Formal Charge0
Complexity1260
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count4
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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