PDL1 degrader-1

PDL1 degrader-1

• UNSPSC Description: PDL1 degrader-1 (compound PMT-O9-1A) is a potent PD-L1 degrader. PDL1 degrader-1 decreases the protein expression of PD-L1. PDL1 degrader-1 shows cytotoxicity. PDL1 degrader-1 shows anticancer activity[1].
• Target Antigen: PD-1/PD-L1
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pmt-o9-1a.html
• Smiles: COC1=C(C2=C[N+]3=C(C4=CC(OC)=C(C=C4CC3)OC)C=C2C=C1)OCCN.[Cl-]
• Molecular Weight: 416.90
• References & Citations: [1]Zeng Z, et al. Advancing Cancer Immunotherapy through Engineering New PD-L1 Degraders: A Comprehensive Study from Small Molecules to PD-L1-Specific Peptide-Drug Conjugates. J Med Chem. 2024 Oct 18.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported