BRD4 degrader-1

BRD4 degrader-1

• UNSPSC Description: BRD4 degrader-1 (Compound ML 1-50) is a monovalent and covalent molecular glue BRD4 degrader. BRD4 degrader-1 targets DCAF16 (E3 ligase) and degrades both the long and short isoforms of BRD4 in cells[1].
• Target Antigen: E1/E2/E3 Enzyme; Epigenetic Reader Domain; Molecular Glues
• Type: Reference compound
• Related Pathways: Epigenetics;Metabolic Enzyme/Protease;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/brd4-degrader-1.html
• Smiles: O=C(N1CCN(S(=O)(C=C)=O)CC1)C[C@H]2C3=NN=C(C)N3C4=C(C(C)=C(C)S4)C(C5=CC=C(Cl)C=C5)=N2
• Molecular Weight: 559.10
• References & Citations: [1]Melissa Lim, et al. DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders.ACS Central Science. DOI: 10.1021/acscentsci.4c00286
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported