BRD4 degrader-1

• UNSPSC Description:

  BRD4 degrader-1 (Compound ML 1-50) is a monovalent and covalent molecular glue BRD4 degrader. BRD4 degrader-1 targets DCAF16 (E3 ligase) and degrades both the long and short isoforms of BRD4 in cells[1].

• Target Antigen:

  E1/E2/E3 Enzyme; Epigenetic Reader Domain; Molecular Glues

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;Metabolic Enzyme/Protease;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/brd4-degrader-1.html

• Smiles:

  O=C(N1CCN(S(=O)(C=C)=O)CC1)C[C@H]2C3=NN=C(C)N3C4=C(C(C)=C(C)S4)C(C5=CC=C(Cl)C=C5)=N2

• Molecular Weight:

  559.10

• References & Citations:

  [1]Melissa Lim, et al. DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders.ACS Central Science. DOI: 10.1021/acscentsci.4c00286

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported