CRM1 degrader 1

• UNSPSC Description:

  CRM1 degrader 1 (1l) is a low toxic chromosome region maintenance 1 (CRM1) degrader. CRM1 is the sole nuclear exporter of several tumor suppressor, a growth regulatory protein as an attractive cancer agent target. CRM1 degrader 1 induces the apoptosis in gastric carcinoma and selectively inhibits proliferation of gastric cancer[1].

• Target Antigen:

  CRM1

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/crm1-degrader-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=CC(OC[C@H]2CC=CC(O2)=O)=C(C=C1)C(C)C

• Molecular Weight:

  260.33

• References & Citations:

  [1]Xu HW, et al. A low toxic CRM1 degrader: Synthesis and anti-proliferation on MGC803 and HGC27. Eur J Med Chem. 2020;206:112708.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2986647-41-8