CRM1 degrader 1

CRM1 degrader 1

• CAS Number: 2986647-41-8
• UNSPSC Description: CRM1 degrader 1 (1l) is a low toxic chromosome region maintenance 1 (CRM1) degrader. CRM1 is the sole nuclear exporter of several tumor suppressor, a growth regulatory protein as an attractive cancer agent target. CRM1 degrader 1 induces the apoptosis in gastric carcinoma and selectively inhibits proliferation of gastric cancer[1].
• Target Antigen: CRM1
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/crm1-degrader-1.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=CC(OC[C@H]2CC=CC(O2)=O)=C(C=C1)C(C)C
• Molecular Weight: 260.33
• References & Citations: [1]Xu HW, et al. A low toxic CRM1 degrader: Synthesis and anti-proliferation on MGC803 and HGC27. Eur J Med Chem. 2020;206:112708.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported