FGFR2 degrader 1

• UNSPSC Description:

  FGFR2 degrader 1 (compound 28E) is a selectively PROTACS degrader of FGFR2, with the DC50 of 0.645 nM. FGFR2 plays an important role in cancer research (Pink: ligand of target protein; (HY-13304) black: linker; blue: ligand of E3 ligase)[1].

• Target Antigen:

  FGFR; PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/fgfr2-degrader-1.html

• Smiles:

  O=C1N(C2C(NC(CC2)=O)=O)C(C3=CC(NCCCCCC(NCCN4N=CC(/C=C/C5=NNC6=CC=C(O[C@H](C)C7=C(Cl)C=NC=C7Cl)C=C56)=C4)=O)=CC=C31)=O

• Molecular Weight:

  812.70

• References & Citations:

  [1]Zuli Hu, et al. Design, synthesis and antitumor activity of a novel FGFR2-selective degrader to overcome resistance of the FGFR2V564F gatekeeper mutation based on a pan-FGFR inhibitor. Eur J Med Chem. 2024 Sep 5:275:116612.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported