PDL1 degrader-2

PDL1 degrader-2

• UNSPSC Description: PD-L1 degrader-2 (Compound B3) is an orally active AUTAC degrader, that degrades PD-L1 through autophagy-lysosome pathway with a DC50 of 0.5 μM. PD-L1 degrader-2 exhibits inhibitory activity against PD-1/PD-L1 interaction with an IC50 of 22.8 nM. PD-L1 degrader-2 upregulates the expressions of Atg9b, Lamp1 and Mitf, and activates the autophagy lysosome system. PD-L1 degrader- exhibits antitumor efficacy in CT26 mouse model[1]. (Pink: autophagy-lysosome activator (HY-159894); Black: linker (HY-W015088); Blue: PD-L1 ligand (HY-169365))
• Target Antigen: AUTACs; Autophagy; PD-1/PD-L1
• Type: Reference compound
• Related Pathways: Autophagy;Immunology/Inflammation;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-pd-l1-degrader-3.html
• Smiles: CC1=C(C2=NN=C(NC3=CC(CNCCOCCOCCOCCNCC4=CC=CC(NC5=NN=C(C6=CC=CC=C6)O5)=C4)=CC=C3)O2)C=CC=C1C7=CC=CC=C7
• Molecular Weight: 780.91
• References & Citations: [1]Wang K, et al., Discovery of small molecules for autophagy-lysosome degradation of immune checkpoint proteins. Eur J Med Chem. 2024 Dec 15;280:116958.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported