BMS-196085

• UNSPSC Description:

  BMS-196085 is an orally active, potent and selective full agonist against human β3 adrenergic receptor with a Ki value of 21 nM. BMS-196085 also has partial agonist activity at the β1 receptor. BMS-196085 is promising for research of obesity and type-II diabetes[1][2].

• Target Antigen:

  Adrenergic Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/bms-196085.html

• Smiles:

  O[C@H](C1=CC(NS(C)(=O)=O)=C(C=C1)O)CN[C@@H](C2=CC=C(C=C2)OC(F)F)CC3=CC=CC=C3

• Molecular Weight:

  492.54

• References & Citations:

  [1]Gavai A V, et al. BMS-196085: a potent and selective full agonist of the human β3 adrenergic receptor[J]. Bioorganic & medicinal chemistry letters, 2001, 11(23): 3041-3044.|[2]Hu B, et al. Orally bioavailable β3-adrenergic receptor agonists as potential therapeutic agents for obesityand type-II diabetes[J]. Progress in medicinal chemistry, 2003, 41: 167-194.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 1

• CAS Number:

  170686-10-9