BMS-196085

• Description:

  BMS-196085 is an orally active, potent and selective full agonist against human β3 adrenergic receptor with a Ki value of 21 nM. BMS-196085 also has partial agonist activity at the β1 receptor. BMS-196085 is promising for research of obesity and type-II diabetes[1][2].

• UNSPSC:

  12352005

• Target:

  Adrenergic Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/bms-196085.html

• Smiles:

  O[C@H] (C1=CC (NS (C) (=O) =O) =C (C=C1) O) CN[C@@H] (C2=CC=C (C=C2) OC (F) F) CC3=CC=CC=C3

• Molecular Formula:

  C24H26F2N2O5S

• Molecular Weight:

  492.54

• References & Citations:

  [1]Gavai A V, et al. BMS-196085: a potent and selective full agonist of the human β3 adrenergic receptor[J]. Bioorganic & medicinal chemistry letters, 2001, 11 (23) : 3041-3044.|[2]Hu B, et al. Orally bioavailable β3-adrenergic receptor agonists as potential therapeutic agents for obesityand type-II diabetes[J]. Progress in medicinal chemistry, 2003, 41: 167-194.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• CAS Number:

  170686-10-9