JMS-175-2

• Description:

  JMS-175-2 is a potent agonist of BRCC36 isopeptidase complex (BRISC), with the IC50 of 3.8 μM. JMS-175-2 plays an important role in Type I interferon-mediated diseases[1].

• UNSPSC:

  12352005

• Target:

  Deubiquitinase

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/jms-175-2.html

• Purity:

  98.13

• Smiles:

  ClC1=CC=CC(Cl)=C1C(N2C=C(NC(C3=C(Cl)C=CC=C3Cl)=O)C(C(NC4CCNCC4)=O)=N2)=O

• Molecular Formula:

  C23H19Cl4N5O3

• Molecular Weight:

  555.24

• References & Citations:

  [1]"Francesca Chandler, et al. Molecular glues that inhibit specific Zn2+-dependent DUB activity and inflammation. bioRxiv [Preprint]. 2024 Sep 7:2024.09.07.611787."

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3042887-70-4]