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PRMT5-IN-30

CAT: 0804-HY-Q36691Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-Q36691Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PRMT5-IN-30 (compound 17) is a potent and selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 0.33 μM and a Kd of 0.987 μM. PRMT5-IN-30 exhibits a broad selectivity against a panel of other methyltransferases. PRMT5-IN-30 inhibits PRMT5 mediated SmD3 methylation[1].
CAS Number
330951-01-4
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/prmt5-in-30.html
Purity
99.17
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C1(SCC(=O)NC2C=CC=CC=2C(OC)=O)NC2C(=CC=C(OC)C=2)N=1
Molecular Formula
C18H17N3O4S
Molecular Weight
371.41
Precautions
H315, H319, H320
References & Citations
[1]Ruifeng Mao, et al. Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization. J Med Chem. 2017 Jul 27;60 (14) :6289-6304.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Dedicated for Diverse Library
Clinical Information
No Development Reported
Isoform
PRMT5

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