Pifithrin-α (hydrobromide)

CAT: 0804-HY-15484-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15484-01Size:5 mg
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Description
Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.
CAS Number
[63208-82-2]
Product Name Alternative
Pifithrin hydrobromide; PFTα hydrobromide
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Aryl Hydrocarbon Receptor; Ferroptosis; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Pifithrin-_alpha_-hydrobromide.html
Purity
98.58
Solubility
DMSO : ≥ 50 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N=C1SC2=C(CCCC2)N1CC(C3=CC=C(C)C=C3)=O.[H]Br
Molecular Formula
C16H19BrN2OS
Molecular Weight
367.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Yu W, et al. Cyclosporine A Suppressed Glucose Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition. Int J Biol Sci. 2016 Jan 1;12 (2) :198-209.|[2]Hoagland MS, et al. The p53 Inhibitor Pifithrin-α Is a Potent Agonist of the Aryl Hydrocarbon Receptor. J Pharmacol Exp Ther. 2005 Aug;314 (2) :603-10.|[3]Kuang SQ, et al. FOXE3 mutations predispose to thoracic aortic aneurysms and dissections. J Clin Invest. 2016 Mar 1;126 (3) :948-61.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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