Pifithrin-μ

CAT: 0804-HY-10940-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-10940-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Pifithrin-μ is an inhibitor of p53 and HSP70, with antitumor and neuroprotective activity.
CAS Number
[64984-31-2]
Product Name Alternative
PFTμ; 2-Phenylethynesulfonamide
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; HSP; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Pifithrin-_mu_.html
Concentration
10mM
Purity
99.69
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C#CC1=CC=CC=C1)(N)=O
Molecular Formula
C8H7NO2S
Molecular Weight
181.21
Precautions
H302, H315, H319, H335
References & Citations
[1]Strom E, et al. Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat Chem Biol. 2006 Sep;2 (9) :474-9. Epub 2006 Jul 23.|[2]Zhou Y, et al. Pifithrin-μ is efficacious against non-small cell lung cancer via inhibition of heat shock protein 70. Oncol Rep. 2017 Jan;37 (1) :313-322.|[3]Glas M, et al. Neuroprotection with the P53-Inhibitor Pifithrin-μ after Cardiac Arrest in a Rodent Model. Shock. 2018 Feb;49 (2) :229-234.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP70

Alternative Products

CatalogName
S1816-25mgPifithrin-α
2653/10Pifithrin-μ
MBS130140-01Pifithrin-?
B4813-10Pifithrin-β
BUP14339-01Pifithrin-µ
1554-10Pifithrin-ɑ
563407Pifithrin-µ
MBS3608949-01Pifithrin-mu

Popular Products