Pifithrin-μ

• Description:

  Pifithrin-μ is an inhibitor of p53 and HSP70, with antitumor and neuroprotective activity.

• Product Name Alternative:

  PFTμ; 2-Phenylethynesulfonamide

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Autophagy; HSP; MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Pifithrin-_mu_.html

• Concentration:

  10mM

• Purity:

  99.69

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=S (C#CC1=CC=CC=C1) (N) =O

• Molecular Formula:

  C8H7NO2S

• Molecular Weight:

  181.21

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Strom E, et al. Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat Chem Biol. 2006 Sep;2 (9) :474-9. Epub 2006 Jul 23.|[2]Zhou Y, et al. Pifithrin-μ is efficacious against non-small cell lung cancer via inhibition of heat shock protein 70. Oncol Rep. 2017 Jan;37 (1) :313-322.|[3]Glas M, et al. Neuroprotection with the P53-Inhibitor Pifithrin-μ after Cardiac Arrest in a Rodent Model. Shock. 2018 Feb;49 (2) :229-234.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  HSP70

• CAS Number:

  64984-31-2