Galanthamine (hydrobromide)

• Description:

  Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC50 of 0.35 µM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α3β4, α4β2, α6β4 nicotinic receptors (nAChRs) . Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD) [1][2][3].

• Product Name Alternative:

  Galantamine (hydrobromide)

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  Cholinesterase (ChE) ; nAChR

• Type:

  Natural Products

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Galanthamine-hydrobromide.html

• Purity:

  99.93

• Solubility:

  DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 16.67 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles:

  O[C@@H]1C[C@@H]2OC3=C4C(CN(C)CC[C@]42C=C1)=CC=C3OC.Br

• Molecular Formula:

  C17H22BrNO3

• Molecular Weight:

  368.27

• Precautions:

  H301

• References & Citations:

  [1]L J Scott, et al. Galantamine: a review of its use in Alzheimer's disease. Drugs. 2000 Nov;60 (5) :1095-122.|[2]Marek Samochocki, et al. Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. Pharmacol Exp Ther. 2003 Jun;305 (3) :1024-36.|[3]Acharya Balkrishna, et al. Anti-Acetylcholinesterase Activities of Mono-Herbal Extracts and Exhibited Synergistic Effects of the Phytoconstituents: A Biochemical and Computational Study. Molecules. 2019 Nov; 24 (22) : 4175.|[4]Balpreet Matharu, et al. Galantamine inhibits beta-amyloid aggregation and cytotoxicity. J Neurol Sci. 2009 May 15;280 (1-2) :49-58.|[5]Debby Van Dam, et al. Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model. Psychopharmacology (Berl) . 2005 Jun;180 (1) :177-90.|[6]Johan Monbaliu, et al. Pharmacokinetics of galantamine, a cholinesterase inhibitor, in several animal species. Arzneimittelforschung. 2003;53 (7) :486-95.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• Isoform:

  AChE

• Citation 01:

  Acta Pharmacol Sin. 2024 Jun;45 (6) :1160-1174.|Antioxidants (Basel) . 2022 Jun 23;11 (7) :1228.|Free Radic Biol Med. 2019 Dec;145:20-32.|Heliyon. 2024 Jun 3;10 (11) :e32322.|Antioxidants (Basel) . 2022 Feb 14;11 (2) :385.|Asian Pac J Trop Med. 2018, 8 (10) :500-512.|Biochem Pharmacol. 2020 Oct;180:114139.|bioRxiv. 2024 Apr 3:2023.06.02.542933.|bioRxiv. 2025 Sep 21.|J Chromatogr A. 2023 Oct 11:1708:464330.|J Pharmacol Sci. 2022 Apr;148 (4) :364-368.|Microorganisms. 2022 Oct 21;10 (10) :2089.|Nat Commun. 2023 Apr 17;14 (1) :2182.|PLoS Biol. 2024 Jun 27;22 (6) :e3002672.|Research Square Preprint. June 16th, 2022.

• CAS Number:

  [1953-04-4]