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P-nitro-Pifithrin-α

CAT: 0804-HY-130437-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-130437-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
P-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent p53 inhibitor. p-nitro-Pifithrin-α suppresses p53-mediated TGF-β1 expression in HK-2 cells. p-nitro-Pifithrin-α inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice fed a high-fat diet [4]. non-alcoholic fatty liver disease[1][2][3].
CAS Number
389850-21-9
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Caspase; MDM-2/p53; TGF-β Receptor
Type
Reference compound
Related Pathways
Apoptosis; TGF-beta/Smad
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/p-nitro-pifithrin-α.html
Purity
97.0
Solubility
DMSO : 1 mg/mL (ultrasonic; warming)
Smiles
N=C1SC2=C(CCCC2)N1CC(C3=CC=C([N+]([O-])=O)C=C3)=O.[H]Br
Molecular Formula
C15H16BrN3O3S
Molecular Weight
398.27
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Shimizu H, Yisireyili M, Nishijima F, Niwa T. Indoxyl sulfate enhances p53-TGF-β1-Smad3 pathway in proximal tubular cells. Am J Nephrol. 2013;37 (2) :97-103.|[2]Zhang F, et al. Molecular signatures associated with ZIKV exposure in human cortical neural progenitors. Nucleic Acids Res. 2016 Oct 14;44 (18) :8610-8620.|[3]Derdak Z, et al. Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease. J Hepatol. 2013 Apr;58 (4) :785-91.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3

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